【名稱】：1040626【微免碩士班專題演講─成功大學蔡佩珍副教授】
【內容】：講者：蔡佩珍副教授(成功大學醫技系)
講題：我們能做些什麼來更了解困難梭狀桿菌感染？
What can we do to know more about Clostridium difficile infection?
時間：104年6月26日(五)，下午3:30
地點：大愛樓6樓：北二區基地營
※本研習活動時數，已申請教師教學評鑑「教學專業成長研習時數」
摘要：
Toxigenic Clostridium difficile is associated with pseudomembranous colitis in patients receiving long-term broad-spectrum antimicrobials and is also recognized as the major cause of nosocomial diarrhea. Since 2003, the isolation of C. difficile RT027, a hypertoxigenic strain, has been reported worldwide. Increased toxin production and high-level resistance to fluoroquinolones have made this strain a very successful pathogen in healthcare settings. The spread of this strain highlighted the need for epidemiological investigations to characterize currently circulating strains. The changing epidemiology of C. difficile worldwide has been studied extensively and has revealed changes in the ribotypes over the years. In Taiwan, few data concerning the importance of CDI and the incidence of clonal types of C. difficile exist. A complete picture is essential to properly investigate type-specific risk factors for C. difficile infections (CDI) and track long-range transmission. A multiplex PCR method was developed for the detection of C. difficile toxin genes, binary toxin genes and a highly specific marker for PCR ribotype 078 family which is clinical and epidemiological importance. Our research team previously shown that C. difficile infection (CDI) is increased in Taiwan. Dissemination of a predominant C. difficile clone is noted in southern and northern Taiwan. And latter, we confirmed the predominate C. difficile clone is RT126 by PCR-ribotyping. Patients infected by this strains presented a severe pseudomembranous colitis and recurrent CDAD. We also reported the characteristics of the first case of C. difficile PCR ribotype 027 identified in Taiwan. In addition to the infection with a hypertoxigenic C. difficile in the gastrointestinal tract of susceptible hosts, other predisposing factors for CDI are identified, including advanced age, a prolonged hospital stay, and use of acid-suppressive drugs. Of note, exposure to stomach acid-reducing agents, such as Proton pump inhibitors (PPIs), remains a controversial risk factor, and has been associated with CDI in some hospital studies but not in others. A mouse model of antibiotic-associated clostridial colitis was established to examine the role of PPIs for CDI. The CDI mice with PPI treatment exhibited more diarrhea, inflammatory responses and gut barrier permeability than those without PPI exposure, suggesting that PPI exposure increases the severity of intestinal inflammation in the mice with C. difficile colitis. In the face of these changes in the epidemiology and translational study of CDI, surveillance systems and more comprehensive study are necessary to monitor epidemiological trends and pathogenesis.
【報名起始日期】：2015/5/26
【報名迄止日期】：2015/6/25
【參加對象】：慈大教師 慈大職員 慈大學生
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